Yes, the Pharmacy Set, the Freemasonry set, and some other very limited editions have always done well for me. I've been looking for over 20 years for a Franklin Mint Collectors Society Cruise medal to Mexico. I'd pay quadruped spot or more to get one. I have all the others. Additionally, many pieces taken from sets have topical interest and sell well -- Babe Ruth, bla bla bla. Corvette ingots also do well.